Ursodiol is a medicine that changes bile to make it less likely to form gallstones and to protect liver cells.

People use it for small cholesterol gallstones, primary biliary cholangitis, and some forms of drug-induced or pregnancy-related cholestasis. It works slowly. You often need months before you see results, and stopping early can let the problem return.

How to take ursodiol

Take ursodiol exactly as your doctor tells you. Typical doses range from 10 to 15 mg per kilogram of body weight per day, given in divided doses, but your doctor will pick the right amount for your condition. Take tablets with food to help absorption and try to keep the same schedule each day. If you miss a dose, take it when you remember unless it is almost time for the next dose. Don’t double up to catch up.

Side effects and practical warnings

Most people tolerate ursodiol well, but some get stomach pain, diarrhea, or mild nausea. Rarely, it can cause allergic reactions, changes in liver tests, or worsened gallbladder inflammation. If you have severe belly pain, fever, yellowing skin or eyes, or dark urine, contact your doctor right away. People with acute gallbladder inflammation, biliary obstruction, or certain liver tumors should not take ursodiol.

Interactions and tests: Ursodiol can interact with drugs that change liver enzymes or alter bile flow. Tell your clinician about all prescription meds, over-the-counter drugs, and supplements. Your doctor will likely order blood tests to check liver function before and during treatment. Imaging like ultrasound may be used to follow gallstone size if that is the reason for treatment.

Practical tips: If you are trying to dissolve gallstones, expect treatment for six months or longer. Keep follow-up appointments and don’t stop the drug without medical advice. For pregnant or breastfeeding women, talk to your doctor — risks and benefits vary by situation. Store tablets at room temperature and keep them out of reach of children.

When to call your doctor: Report worsening abdominal pain, persistent vomiting, high fever, jaundice, or any new rash or swelling. Also report unusual bruising or bleeding. If your liver tests rise, your doctor may change or stop treatment.

Final thought: Ursodiol is a targeted, often well-tolerated option when used for the right conditions. It takes time to work, so patience and proper monitoring matter. Ask questions, follow directions, and keep your medical team informed about other medicines and symptoms.

Ursodiol is also called ursodeoxycholic acid. Many pharmacies carry the generic, which lowers cost compared with brand names. Some insurance plans cover it, others need prior authorization, so check with your insurer before filling a long-term prescription. If you buy medicines online, use licensed pharmacies and a valid prescription. Avoid websites that offer prescription drugs without asking for a prescription.

Keep an updated list of your medications to share at clinic visits. If you plan surgery or pregnancy, tell your surgeons and obstetrician about ursodiol use. Good records help avoid drug problems and speed safer care. Ask if unsure anytime.